neutralizing pan-tgf-β antibody 1d11  (Genzyme)

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Article Title: Correlations Between Bone Mechanical Properties and Bone Composition Parameters in Mouse Models of Dominant and Recessive Osteogenesis Imperfecta and the Response to Anti-TGF-β Treatment

doi: 10.1002/jbmr.2997

Figure Lengend Snippet: Micro-CT Parameters of Midshaft Femoral Cortical Bone for WT, Crtap −/− , and Col1a2 +/p.G610C Mice

Article Snippet: As described, ( 10 ) 8-week-old female Crtap −/− and Col1a2 +/p.G610C mice were treated for 8 weeks with the pan-TGF-β neutralizing antibody 1D11 (provided by Sanofi Genzyme, Cambridge, MA, USA); control female Crtap −/− , Col1a2 +/p.G610C , and WT mice were treated with a control antibody (13C4) of the same IgG1 isotype that does not inhibit TGF-β.

Techniques: Micro-CT

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Article Title: Correlations Between Bone Mechanical Properties and Bone Composition Parameters in Mouse Models of Dominant and Recessive Osteogenesis Imperfecta and the Response to Anti-TGF-β Treatment

doi: 10.1002/jbmr.2997

Figure Lengend Snippet: (A) The extrinsic mechanical parameters maximum load, stiffness, post-yield energy, and post-yield displacement of femurs from WT, OI control, and anti-TGF-β-treated (OI anti-TGF-β) mice are shown for the Crtap−/− and Col1a2+/p.G610C models. (B) The intrinsic mechanical parameters ultimate strength, elastic modulus, post-yield toughness, and post-yield strain of femurs of WT, OI control, and OI anti-TGF-β mice are shown for the Crtap−/− and Col1a2+/p.G610C models. *p < 0.05. The mechanical parameters of femurs of Crtap−/− mice are parts of the data set included in an earlier publication(10) and are reproduced here for ease in comparing to the data from the Col1a2+/p.G610C model.

Article Snippet: As described, ( 10 ) 8-week-old female Crtap −/− and Col1a2 +/p.G610C mice were treated for 8 weeks with the pan-TGF-β neutralizing antibody 1D11 (provided by Sanofi Genzyme, Cambridge, MA, USA); control female Crtap −/− , Col1a2 +/p.G610C , and WT mice were treated with a control antibody (13C4) of the same IgG1 isotype that does not inhibit TGF-β.

Techniques:

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Article Title: Correlations Between Bone Mechanical Properties and Bone Composition Parameters in Mouse Models of Dominant and Recessive Osteogenesis Imperfecta and the Response to Anti-TGF-β Treatment

doi: 10.1002/jbmr.2997

Figure Lengend Snippet: Bone compositional parameters mineral-to-collagen ratio, carbonate substitution, collagen content, and hydroxyapatite crystallinity determined by Raman spectroscopy of femurs are shown for WT, OI control, and OI anti-TGF-β mice for the Crtap−/− and Col1a2+/p.G610C models. *p < 0.05.

Article Snippet: As described, ( 10 ) 8-week-old female Crtap −/− and Col1a2 +/p.G610C mice were treated for 8 weeks with the pan-TGF-β neutralizing antibody 1D11 (provided by Sanofi Genzyme, Cambridge, MA, USA); control female Crtap −/− , Col1a2 +/p.G610C , and WT mice were treated with a control antibody (13C4) of the same IgG1 isotype that does not inhibit TGF-β.

Techniques: Raman Spectroscopy

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Article Title: Correlations Between Bone Mechanical Properties and Bone Composition Parameters in Mouse Models of Dominant and Recessive Osteogenesis Imperfecta and the Response to Anti-TGF-β Treatment

doi: 10.1002/jbmr.2997

Figure Lengend Snippet: Pearson Correlation Coefficients Between the Mechanical Properties and the Raman Imaging Data for the Crtap −/− Model

Article Snippet: As described, ( 10 ) 8-week-old female Crtap −/− and Col1a2 +/p.G610C mice were treated for 8 weeks with the pan-TGF-β neutralizing antibody 1D11 (provided by Sanofi Genzyme, Cambridge, MA, USA); control female Crtap −/− , Col1a2 +/p.G610C , and WT mice were treated with a control antibody (13C4) of the same IgG1 isotype that does not inhibit TGF-β.

Techniques: Imaging

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Article Title: Correlations Between Bone Mechanical Properties and Bone Composition Parameters in Mouse Models of Dominant and Recessive Osteogenesis Imperfecta and the Response to Anti-TGF-β Treatment

doi: 10.1002/jbmr.2997

Figure Lengend Snippet: Pearson Correlation Coefficients Between the Mechanical Properties and the Raman Imaging Data for the Col1a2 +/p.G610C Model

Article Snippet: As described, ( 10 ) 8-week-old female Crtap −/− and Col1a2 +/p.G610C mice were treated for 8 weeks with the pan-TGF-β neutralizing antibody 1D11 (provided by Sanofi Genzyme, Cambridge, MA, USA); control female Crtap −/− , Col1a2 +/p.G610C , and WT mice were treated with a control antibody (13C4) of the same IgG1 isotype that does not inhibit TGF-β.

Techniques: Imaging